emergence agitation in children
Conditions
Interventions
C:Intravenous injection of normal saline
D:Intravenous injection of 0.5ug/kg dexmedetomidine
K:Intravenous injection of 0.25mg/kg esketamine
DK:Intravenous injection of 0.3ug/kg dexmedetomine + 0.15mg/kg esketamine
Sponsors
the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical Universtiy
Eligibility
Sex/Gender
All
Age
3 Years to 7 Years
Inclusion criteria
Inclusion criteria: (1) Aged 3-7 years ; (2) ASA I-II; (3) Normal liver and kidney function; (4) No previous history of allergy to anesthetics; (5) Signing informed consent.
Exclusion criteria
Exclusion criteria: (1) Known allergy to active ingredients or excipients in anesthetics; (2) glucose-6-phosphate dehydrogenase deficiency; (3) History of arrhythmia, bronchial and cardiovascular diseases, liver dysfunction, etc.; (4) Use of a2 receptor agonists or antagonists; (5) Use of analgesics or sedatives within two days before operation; (6) Mental or nervous system diseases; (7) Use of other experiment drug 3 months before screening period; (8) Patients with history or possibility of difficult airway, such as obstructive sleep apnea syndrome (OSA); (9) Allergic to dexmedetomidine, ketamine, propofol, opioids and other drug ingredients or components; (10) Other conditions judged by the researchers as not suitable to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative agitation in children ; | — |
Secondary
| Measure | Time frame |
|---|---|
| FLACC pain score;Ramsay sedation score;Heart rate and blood pressure;Awaken time;Retention time in PACU; | — |
Countries
China
Contacts
Public ContactHuacheng Liu
he Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical Universtiy
Outcome results
None listed