Multiple System Atrophy
Conditions
Interventions
Sponsors
Shanghai First People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. symptomatic group: (1) Aged 50 to 65 years old; (2) meet the diagnostic criteria of multiple system atrophy established by the International Association of dyskinesia (MDS) in 2008; (3) The fourth part of UMSARS: general disability level 21; (5) Sign informed consent; 2. prodromal patients group: (1) Aged 50 to 60 years old; (2) Patients with rapid eye movement sleep disorder or postural hypotension meeting the diagnostic criteria of PSG; (3) There were no obvious symptoms and signs of extrapyramidal system and cerebellar system that could be observed clinically; or: there were no obvious symptoms and signs of extrapyramidal system or cerebellar system, and doctors could check the signs of extrapyramidal system (updrsiii score 26 points; (5) Sign informed consent. 3. healthy control group: (1) Aged 50 to 65 years old; (2) None of the above-mentioned symptomatic patients and prodromal patients were included in the inclusion criteria; There was no disease listed in the following exclusion criteria; (3) MMSE > 26; (4) Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with Parkinson's disease, Vascular Parkinson's syndrome, stroke, multiple sclerosis, neuromyelitis optica, motor neuron disease, vascular dementia, hydrocephalus, Alzheimer's disease, severe mental disease, encephalitis sequelae, autoimmune encephalitis, adrenoleukodystrophy, subacute combined degeneration, radiation encephalopathy and malignant tumor; 2. Patients with severe peripheral neuropathy, spinal cord injury, brain trauma, history of brain surgery, diabetes mellitus, nephrotic syndrome, uremia, severe spinal degenerative disease, and rapidly progressive leukoaraiosis; 3. Syphilis and HIV infected patients; 4. Patients who are considered unsuitable for this study by other researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurofilament light; | — |
Countries
China
Contacts
Public ContactZhang Xiaojin
Shanghai First People's Hospital
Outcome results
None listed