Infertility
Conditions
Interventions
Gold Standard:1. Endometrial receptivity indexes:
A. Blood flow signals detected by B-ultrasound and molecular tags such as H2AX detected in menstrual blood endometrial cells
B. On trigger day, endometril thickness and blood flow signal detected by B-ultrasound and H2AX and other molecular tags such as H2AX detected in endometria
Index test:The 
expression 
of 
H2AX, 
gammaH2AX,EGFR/HIF-1alpha/VEGF 
be 
in 
tissues/cells 
from 
patients 
with 
and 
non-RIF 
(i.e.,first-time 
Sponsors
Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. RIF patients with more than or equal to 2 times of IVF-ET treatment and the first transplant patients (non-RIF patients); 2. Assisted pregnancy with in vitro fertilization-embryo transfer after ovulation induction by unified antagonist regimen; 3. Blastocyst sterility patients with normal PGS.
Exclusion criteria
Exclusion criteria: 1. Patients with IVF contraindications; 2. Blastocyst sterility patients with abnormal PGS; 3. Patients with stage III/IV endometriosis, based on the Endometriosis grading system of the American Society for Reproductive Medicine; 4. Adenomyosis, uterine fibroids compression uterine cavity line and untreated endometrial diseases; 5. Untreated hydrosalpinx; 6. Patients with a history of chronic diseases such as diabetes, hypertension, hyperthyroidism/hypothyroidism, heart disease, liver and kidney diseases, combined with serious primary medical diseases and psychosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H2AX;gammaH2AX; | — |
Countries
China
Contacts
Public ContactChunxia Ren
Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed