Euthyrox during early pregnancy and its effect on preterm birth of pregnant women with hypothyroxinemia: a multi-center, paralleled, double-blind randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000037569

Enrollment

Unknown

Registered

2020-08-28

Start date

2021-01-01

Completion date

Unknown

Last updated

2020-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical hypothryoidism

Interventions

L-T4 group:L-T4

Control group:Control

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Aged 18-42 years old; 2. Know and agree to participate in this research project; 3. Agree to provide details of TSH, FT4 and TPOAb; 4. TSH 0.44-3.63 mU/L; FT4 12.4-20.4 pmol/L; TPOAb positive; 5. Agree to deliver in specific hospital; 6. Agree follow-up; 7. Singleton; 8. Pregnancy group: gestational age < 8 weeks.

Exclusion criteria

Exclusion criteria: 1. Pre-existing severe diseases; 2. HIV, HBV, HCV-positive; 3. Drug history; 4. Chemical therapy; 5. Fetal malformations; 6. Using amiodarone or lithium carbonate; 7. Abnormal endocrine function; 8. Toxic diffuse goiter or hyper-sensitive to thyroxine; 9. Involved in other clinical trials.

Design outcomes

Primary

Measure	Time frame
preterm birth;	—

Countries

China

Contacts

Public ContactFan Jianxia

International Peace Maternity and Child Health Hospital

fanjianxia122@126.com+86 18017316031

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026