asthma
Conditions
Interventions
Case series:bronchoscopy cryo-balloons
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adults 18-65 years old with asthma; 2. Have a history of asthma with a clear diagnosis and need to take asthma in the past 6 months The control drugs are as follows: high-dose ICS (inhaled glucocorticoid) beclomethasone >=1000ug/day (or equivalent drugs, other drugs and equivalent doses refer to Table 1 below) and LABA (long-acting ß2 receptor agonist) salmeterol >=100ug/day (or equivalent drugs). Other drugs that are allowed to be taken at the same time, including leukotriene modulators and OCS (oral glucocorticoid) =45% of the predicted value; 5. Patients who have no history of smoking or have smoked less than 10 packs for at least six months; 6. Baseline AQLQ (Asthma Quality of Life Questionnaire) score <=6.25; 7. Patients who have good compliance and can be followed up in outpatient clinics.
Exclusion criteria
Exclusion criteria: 1) FEV1 before bronchodilator use should account for less than 45% of the predicted value; 2) More than 3 hospitalizations due to worsening asthma in the past 12 months; 3) Need to use antibiotics for lower respiratory tract infections more than 3 times in the past 12 months; 4) In the past 12 months, oral glucocorticoids have been used due to worsening asthma more than 4 times; 5) Acute attack of chronic sinusitis; 6) Poorly controlled gastroesophageal reflux disease is defined as a significant increase in treatment in the past 6 weeks; 7) Hypersensitivity to drugs necessary for bronchoscopy (such as lidocaine, benzodiazepine); 8) Implantable electrical stimulation devices are installed in the patient's body, such as pacemakers and cardiac defibrillators; 9) Are using immunosuppressants (except glucocorticoids), beta-adrenergic receptor blockers, or anticoagulants; 10) Have a history of fatal asthma; 11) Uncontrolled severe obstructive sleep apnea; 12) Be admitted to ICU due to asthma attack within 2 years before treatment; 13) Patients with unhealed blood diseases or malignant tumors, and uncorrected blood coagulation disorders; 14) Patients with lung CT showing lower lobe bronchial stenosis or complete distal atelectasis, or other severe bronchial and lung solid diseases; 15) The investigator judges that the patient has poor compliance and cannot complete the study as required, or believes that the patient has other medical conditions that are not suitable for this study; 16) There are contraindications related to bronchoscopy; 17) Women who are pregnant or breastfeeding or patients who have a childbirth plan within the next year; 18) Patients who have previously received bronchial cryo-balloon therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect and safety; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life;adverse event; | — |
Contacts
Public ContactLi Xuan
Shanghai Tenth People's Hospital
Outcome results
None listed