lumbar disc herniation
Conditions
Interventions
experimental group:nucleus pulposus enucleation under intervertebral foramen endoscope
control group:intervertebral disc fusion
Sponsors
Shanghai Public Health Clinical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with clinically diagnosed lumber disc herniation with imaging evidence, which meets McCulloch's diagnostic criteria of lumbar disc herniation proposed in 1980; 2. Over 50% secondary spinal stenosis rate as shown on lumbar magnetic resonance images; 3. Patients agree to undergo transforaminal endoscopy and will not participate in other clinical trials to avoid the factors that influence study bias; 4. Meeting Chinas diagnostic criteria for human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) and treatment principles (2001): patients have all of the following conditions can be diagnosed suffering from AIDS, 1) an epidemiological history; 2) confirmed HIV antibody-positive; 3) serum HIV/RNA-positive; 4) one of any clinical manifestation. Patients can also be diagnosed with AIDS if they exhibit confirmed HIV antibody-positive or serum HIV-RNA-positive in addition to CD4+ T lymphocytes < 200/uL.
Exclusion criteria
Exclusion criteria: (1) Patients with coronary atherosclerosis and/or other basic diseases; (2) Patients with stroke, malignant tumor, brain injury and/or other diseases that affect the follow-up effect; (3) Patients with surgical contraindications including severe diabetes mellitus, liver disease, and abnormal coagulation function; (4) Patients who do not agree to be treated with transforaminal endoscopic surgery; (5) Patients with neuropsychiatric disorders; (6) Patients with lumbar disc herniation and severe lumbar degenerative disease caused by other complex causes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change of symptom improvement rate evaluated by JOA score at 24 months after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The change of symptom improvement rate at 6 and 12 months after surgery;Pain improvement rate evaluated by VAS at 6, 12 and 24 months after surgery;Operation time, amount of blood loss, hospital days;Recurrence rate of lumbar disc herniation at 6, 12 and 24 months after surgery;Incidence of adverse reactions at 6, 12 and 24 months after surgery; | — |
Countries
China
Contacts
Public ContactMing Lu
Shanghai Public Health Clinical Center
Outcome results
None listed