Multidrug resistant tuberculosis
Conditions
Interventions
Gold Standard:Positive culture of sputum Mycobacterium tuberculosis
The susceptibility test of Mycobacterium tuberculosis in sputum showed that isoniazid and rifampicin were simultaneously resistant
Sponsors
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Positive culture of sputum Mycobacterium tuberculosis; 2) The susceptibility test of Mycobacterium tuberculosis in sputum showed that isoniazid and rifampicin were simultaneously resistant; 3) The age range is between 18-65 years old;
Exclusion criteria
Exclusion criteria: 1) Ten items of drug sensitivity (screening) to exclude extensively drug-resistant tuberculosis (XDR-TB); 2) Those under the age of 18 or over 65; 3) The continuous course of disease is more than 5 years and the retreatment is more than 2 times; 4) Chest CT shows: the diameter of the lung cavity is greater than 5cm, and the cavity is greater than 5; 5) Emergency medical history of massive hemoptysis; 6) Body mass index (BMI index) is less than 19; 7) Combined with extrapulmonary tuberculosis such as lymphatic tuberculosis, bone tuberculosis, and brain tuberculosis; 8) Combined with mental illness or family history of mental illness; combined with respiratory failure; combined with severe peptic ulcer disease; combined with malignant tumor; combined with AIDS; combined with autoimmune disease; 9) Legally disabled patients; 10) Women who are pregnant, preparing to become pregnant or breast-feeding; 11) The QT interval is greater than 500 milliseconds after correction; 12) Abnormal liver function (AST, ALT exceeding 1.2 times the upper limit of normal) and/or HbsAg, HbeAg and HbcAg positive at the same time; 13) Diabetes with poor blood glucose control (fasting blood glucose greater than 7mmol/L, postprandial greater than 11mmol/L); 14) Those with incomplete imaging data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chest CT; | — |
Countries
China
Contacts
Public ContactLu Zhenhui
Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed