outlet obstructed constipation
Conditions
Interventions
Sponsors
Anhui Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. There was evidence of outlet obstruction and met Rome IV diagnostic criteria for functional constipation 2. Aged 18 to 65 years old male and female; 3. Colonoscopy was performed in a Grade-A hospital one year before the enrollment to exclude intestinal cancer, ulcer, inflammation or other organic intestinal diseases; 4. B-ultrasound examination was performed in a Grade-A hospital one year before admission to exclude hepatobiliary and pancreatic diseases; 5. The patients with normal ECG examination in our center one month before admission (QT interval was within normal range).
Exclusion criteria
Exclusion criteria: 1. Have a history of abdominal surgery; 2. Organic diseases of digestive system (including polyps, inflammatory bowel disease, tumor, celiac disease, lactose intolerance, etc.); 3. Any antispasmodic and analgesic drugs, gastrointestinal motility drugs, acid inhibitors, microecological agents, antibiotics, antidepressants, etc. were used within 2 weeks before enrollment; 4. B ultrasound examination of liver, gallbladder and pancreas diseases; 5. People with hypertension and unstable blood pressure control; 6. Patients with diabetes mellitus, thyroid disease, systemic sclerosis, systemic lupus erythematosus, etc; 7. Patients with severe psychological disorders; 8. pregnant women, lactating women or planned pregnancies; 9. There are allergic patients taking polyethylene glycol 4000 powder; 10. Observation contents: (1) Basic information collection; (2) Constipation symptom severity score pac-sym; (3) Constipation quality of life score pac-qol; (4) Anal sphincter pressure during defecation; (5) Changes of serum psychosomatic neurotransmitters (conditional units).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PAC-SYM;PAC-QOL;anal defedating pressure;Changes of Serum Psychological Related Neurotransmitters; | — |
Countries
China
Contacts
Public ContactYu Yue
Anhui Provincial Hospital
Outcome results
None listed