chemotherapy-induced nausea and vomiting
Conditions
Interventions
1:Dex+placebo
2:MA+Dex
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
Male
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with solid malignant tumor confirmed by pathology; 2. WHO ECOG Physical Strength score 0-1, life expectancy =6 months; 3. Newly treated patients who have not received chemotherapy before; 4. The patient intends to receive chemotherapy based on high-dose cisplatin (=50mg/?); 5. The laboratory indicators before enrollment showed good bone marrow, liver and kidney reserve function 6. The patient signs informed consent.
Exclusion criteria
Exclusion criteria: 1. Nausea or vomiting occurred within 24 hours before enrollment; 2. Neurological disease or severe cognitive impairment; 3. Previous endocrine system diseases; Symptomatic or suspected clinical brain metastases; 4. Uncontrolled congestive heart failure, arrhythmia, or acute myocardial infarction in the past 6 months; 5. Uncontrollable peptic ulcer; History of diabetes and hypertension; A history of cortisol treatment; 6. Symptomatic thrombosis or thrombophlebitis; 7. Receive other drugs that may affect the antiemetic effect, such as PPI, H2 blocker, H2 blocker, amphotin and sedative drugs; 8. Unable to take or absorb oral drugs; Allergies to basic antiemetic drugs are known;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nausea, vomiting; | — |
Contacts
Public ContactCheng Yi
West China Hospital, Sichuan University
Outcome results
None listed