autoimmune encephalitis
Conditions
Interventions
Gold Standard:the final diagnosis based on the manifestation and antibody test results
Index test:TSPO-PET/MRI, 
FDG-PET 
and 
MRI
Sponsors
Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for AE patients: 1) Patients with antibody positive and antibody negative autoimmune encephalitisis which is confirmed according to the diagnostic criteria; 2) Older than 18 and younger than 80, without gender restriction; 3) Able to obtain complete follow-up information, understand the content of this study and sign informed consent. Inclusion criteria for healthy subjects: 1) Without previous history of encephalitis or family history of encephalitis; 2) Be in good health and have not felt any discomfort recently; 3) No obvious abnormalities found in the physical examination.
Exclusion criteria
Exclusion criteria: Exclusion criteria for AE patients: 1) In the past 5 years, there have been clearly diagnosed central nervous system diseases causing epilepsy, cognitive impairment or abnormal mental symptoms, including Alzheimer's disease, Parkinson's disease, central nervous system tumors, schizophrenia, etc. However, patients with other systemic tumor diseases should not be excluded. 2) Breastfeeding and/or pregnant women; 3) History of brain surgery; 4) Patients with serious medical diseases (such as heart, liver, lung, renal insufficiency); 5) Patients unable to tolerate the examination due to severe mental and behavioral abnormalities, central respiratory failure; 6) The researcher believes that the subject may not be able to complete the study or comply with the requirements of the study; Exclusion criteria for healthy subjects: 1) In the past 5 years, there have been clearly diagnosed central nervous system diseases causing epilepsy, cognitive impairment or abnormal mental symptoms, including Alzheimer's disease, Parkinson's disease, central nervous system tumors, schizophrenia, etc. 2) those suffering from tumor diseases; 3) Patients with hypertension, diabetes, gout, thyroid diseases, liver and kidney dysfunction, heart and lung failure, blood system diseases, and severe systemic infectious diseases; 4) Suffering from mental illness; 5) In the opinion of the researcher, the subject may not be able to complete the study or comply with the requirements of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SUV;SUVR; | — |
Countries
China
Contacts
Public ContactYong Hao
Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital
Outcome results
None listed