Thyroid cancer
Conditions
Interventions
Gold Standard:Pathological diagnosis and NGS sequencing
Index test:Use Raman microscope to detect Raman peaks in serum and urine, and conduct in-depth study and analysis of FNA benign and malignant nodules to determine Raman markers for accurate differenti
Sponsors
Shanghai 10th People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: FNA patients: (1) Thyroid B-ultrasound prompts thyroid nodules with FNA detection; (2) Patients aged 18-65 years; (3) Liver and kidney functions are normal. RAI-R patients: (1) DTC patients with no obvious abnormal liver and kidney function; (2) BRAFV600E and or TERT promoter mutations (C228T/C250T); iodine absorption is reduced by more than half within one year.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with nodules: (1) pregnant or lactating women; (2) neutrophil count =7; (5) Malignant Tumor history; history of important organ transplantation; (6) Other diseases that the investigator believes are not suitable for inclusion in the group. RAI-R patients: on the basis of the above, plus (1) combined with other tumors; (2) the patient died during follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Raman picks for serum and urine in patients with thyroid cancer;Sensitivity, specificity, accuracy; | — |
Countries
China
Contacts
Public ContactLv Zhongwei
Shanghai 10th People's Hospital
Outcome results
None listed