Recurrent of lower grade glioma after radiotherapy and chemotherapy
Conditions
Interventions
Recurrent cohort:NA
Sponsors
Huashan Hospital affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients who have undergone surgical resection or biopsy, and are confirmed to be WHO II and WHO III gliomas by pathological examination. 2. Received radiotherapy and/or chemotherapy after surgery. 3. Have enhanced MR examination and two experienced radiologists consider the tumor recurrence. 4. Agree to receive surgical treatment again to obtain tumor tissue samples, and postoperative pathology excludes patients with radiation necrosis. 5. Age over 18 years old and under 70 years old, no gender limit. 6. The subject was completely voluntary and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Accompanied by severe heart, lung, liver and kidney and other important organ diseases, poor general condition, and obvious abnormalities in blood coagulation, the investigator's assessment or consultation with relevant departments believes that there is a contraindication, high risk or unsuitable for surgery. 2. The subject cannot undergo MRI examination. 3. The subject is unwilling to undergo another operation. 4. Pregnant or breastfeeding. 5. Life expectancy <3 months. 6. Have a serious mental illness. 7. Currently participating in another drug clinical trial. 8. Subjects or guardians do not want to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The genome of lower-grade gliomas that relapse after radiotherapy and chemotherapy;The DNA methylome of lower-grade gliomas that relapse after radiotherapy and chemotherapy; | — |
Countries
China
Contacts
Public ContactFeili Liu
Huashan Hospital affiliated to Fudan University
Outcome results
None listed