Breast cancer
Conditions
Interventions
control group:chemotherapy
experimental group:Chemotherapy + probiotics
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The patients diagnosed as invasive breast cancer by histopathology and have received breast cancer surgery (including simple mastectomy + sentinel lymph node biopsy, modified radical mastectomy and breast conserving radical mastectomy); 2. Patients who received chemotherapy for the first time after breast cancer surgery and received Tec regimen; 3. The survival time of patients with karnofshy score >= 75 was more than 3 months; 4. The patients had no serious cardiovascular and cerebrovascular diseases, digestive tract diseases or mental diseases, and their blood routine, liver and kidney functions, cardiac functions and electrocardiogram were normal before chemotherapy; 5. Ask for informed consent of patients and volunteer for the test.
Exclusion criteria
Exclusion criteria: 1. Patients with previous history of other malignant tumors; 2. Patients with gastrointestinal diseases such as inflammatory bowel disease, diverticulitis, chronic diarrhea or constipation; 3. Patients with oral antibiotics within one month before chemotherapy, such as penicillins, cephalosporins, aminoglycosides and macrolides.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete Blood Count;Stool routine;Tumor markers;nutritional indicator; | — |
Countries
China
Contacts
Public ContactQian Mingping
Shanghai Tenth People's Hospital
Outcome results
None listed