chronic actinic dermatitis
Conditions
Interventions
normal control group:Nil
CAD patients group:Nil
Sponsors
Shanghai Skin Disease Hospital
Eligibility
Sex/Gender
Male
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: Normal control group: 1. The subjects are healthy males, aged 45-65 years old, easy to move; 2. The subjects voluntarily participated in the study and signed the informed consent form; 3. The subjects promise not to prepare for pregnancy during the study; 4. The subjects who are taking nutrition and health care products should keep their original taking habits during the study, and explain to the research center; 5. Subjects who are using hormone replacement therapy should ensure to maintain their original use habits during the study period, and those who do not use hormone should not use this kind of hormone during the study period; 6. Subjects are able to ensure that the test site are not subjected to severe scrubbing or SPA treatment during the study period; 7. No topical or systemic corticosteroids were used in the past month; 8. The subjects are able to comply with the research requirements and return visit according to the regulations. CAD patients group: 1. The subjects are males, aged 45-65 years old, easy to move; 2. According to the diagnosis of CAD, f necessary, light test, light patch test and histological examination are carried out to further confirm the diagnosis; 3. The subjects voluntarily participated in the study and signed the informed consent form; 4. The subjects promise not to prepare for pregnancy during the study; 5. The subjects who are taking nutrition and health care products should keep their original taking habits during the study, and explain to the research center; 6. Subjects who are using hormone replacement therapy should ensure to maintain their original use habits during the study period, and those who do not use hormone should not use this kind of hormone during the study period; 7. Subjects are able to ensure that the test site are not subjected to severe scrubbing or SPA treatment during the study period; 8. The subjects didn't receive systematic corticosteroids therapy, systematic use of corticosteroids should be avoided during the study, and the specific treatment plan should be informed to the researchers; 9. The subjects are able to comply with the research requirements and return visit according to the regulations.
Exclusion criteria
Exclusion criteria: Normal control group: 1. The subjects suffered from diseases or conditions that may affect the results of the study; 2. Subjects have chronic skin diseases such as atopic dermatitis, psoriasis and eczema; 3. Large-area damage, scar, stain, tattoo and other factors which may affect the test; 4. Subjects can not avoid severe scrubbing or excessive soaking of test parts in daily life; 5. Subjects participated in other clinical researchers in recent 3 months. CAD patients group: 1. CAD are excluded by clinical observation or related examination (light test, light patch test, histological examination, etc.); 2. The subjects suffered from diseases or conditions that may affect the results of the study; 3. Subjects have chronic skin diseases such as atopic dermatitis, psoriasis and eczema; 4. Large-area damage, scar, stain, tattoo and other factors which may affect the test; 5. Subjects can not avoid severe scrubbing or excessive soaking of test parts in daily life; 6. Subjects participated in other clinical researchers in recent 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MIF protein expression in peripheral blood;MIF protein expression in keratinocytes;non-invasive skin test results; | — |
Secondary
| Measure | Time frame |
|---|---|
| proportion and count of eosinophils in peripheral blood;total IgE level in peripheral blood; | — |
Countries
China
Contacts
Public ContactMa Yuelong
Shanghai Skin Disease Hospital
Outcome results
None listed