Parkinson 's disease
Conditions
Interventions
Intervention :TBS mode rTMS
control:TBSmode sham stimulation rTMS
Sponsors
Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1)Patients at age between 40 and 75 years old. 2) patients have been clinically diagnosed with PD according to the 2015 International MDS PD criteria. 3) patients whose symptoms have been well controlled in the condition of stable dopaminergic treatment for at least 1 month before the recruitment. 4) patients that have obvious dyskinesia (MDS-UPDRS-IV item 2 score is above 2 points and MDS-UPDRS-IV item 1 score is above 2 points). 5) patients or their legal guardians have agreed to participate the study and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Pregnant or lactating women; 2) patients that have severe cognitive impairment or psychiatric symptoms; 3) patients that have severe liver and kidney impairment; 4) patients that have been participating the other clinical studies or participated other clinical studies within the previous 30 days at the recruitment; 5) patients that are unable to cooperate with the assessments; 6)patients with metal foreign bodies in the heads or pacemakers or cochlear implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the difference value between the CAPSIT score at baseline and CAPSIT score after the initiation of the intervention; | — |
Secondary
| Measure | Time frame |
|---|---|
| the difference value between the daily levodopa dosage and levodopa equivalent dosage at baseline and the daily levodopa dosage and levodopa equivalent dosage after initiation o the intervention;the difference value between the PD-NMSQ30 score at baseline and PD-NMSQ30 score after initiation o the intervention;the change between the activated brain areas and network at baseline and after the intervention;the change between the F18-FDG brain metabolism at baseline and the F18-FDG metabolism after the intervention;the association between the polymorphism of NMDA and BDNFgenes and the dyskinesia of PD;the difference value between the PDQ-8 score at baseline and the PDQ-8 score after intervention;the change between the tremor the parameters of the electromyography at baseline and the parameters of tremor electromyograhpy after intervention;the difference value between CGI score at baseline and CGI score after intervention; | — |
Countries
China
Contacts
Public ContactZhenguo Liu
Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine
Outcome results
None listed