Cancer Pain
Conditions
Interventions
control group:placebo
experimental group:Oral magnesium supplement (magnesium threonate)
Sponsors
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Subjects must meet all the following conditions before entering the trial. 1) For cancer pain patients, oral morphine sulfate sustained-release tablets/ OxyContin sustained-release tablets, morphine 4 points or higher than cancer pain, or outbreak pain > 3 times/day; 3) Expected survival time is over 3 months; 4) Subjects can follow the drug dosage and visit plan;
Exclusion criteria
Exclusion criteria: Subjects must exclude all the following conditions before entering the trial. 1) The general condition is poor, unable to describe the symptoms objectively, or if there is a serious infection, respiratory insufficiency, etc., cannot actively cooperate; 2) People with severe respiratory system, cardiovascular system disease, liver and kidney dysfunction; 3) People with allergic diseases and allergic constitution; those who are allergic to magnesium threonate drugs; 4) Those who suspect or do have a history of drug abuse and drug addiction; 5) Breastfeeding and pregnant women: subjects who have a pregnancy plan within 1 month after the test (including male subjects); 6) Patients who have participated in the drug trial (including the trial drug) within 3 months before the trial; 7) The sponsor or investigator directly involved in the trial or their family members; 8) The researcher believes that there are other reasons that cannot be selected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of opioid tolerance within three months; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS visual analogue pain score;Constipation Quality of Life Score (PAC-QOL);Bowel Function Index (BFI);Number and extent of burst pain;High-throughput DNA sequencing of intestinal flora; | — |
Countries
China
Contacts
Public ContactKe Ma
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed