Chronic Hepititis B
Conditions
Interventions
LdT group, TDF group, ETV group, TAF group, Interferon group:Nil
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: a. Chronic hepatitis B patients; b. The age ranged from 18 to 65 years old; c. Can understand and sign the informed consent form normally.
Exclusion criteria
Exclusion criteria: a. Patients with infection within 3 months; b. Antibiotics (such as cephalosporins and quinolones) were used within 3 months; c. Those who have taken probiotics, prebiotics and Miya within 3 months; d. Diabetes mellitus was complicated; e. Obesity or significantly low body weight; f. There were obvious atherosclerosis; g. Hypertension; h. Severe liver disease; i. History of gastrointestinal surgery; j. Inflammatory bowel disease; k. Irritable bowel syndrome; l. History of malignant tumor; m. Autoimmune diseases (such as autoimmune hepatitis, etc.) n. Parkinson's disease, Alzheimer's disease and stroke; o. Mental illness; p. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the time required for HBV DNA to turn negative and ALT / AST to return to normal after taking medicine;the time and proportion of large three positive to small three positive (e antigen serological conversion);The decrease range of surface antigen and e antigen;The time and ratio of surface antigen turning negative; | — |
Secondary
| Measure | Time frame |
|---|---|
| Renal function (CRE, EGFR, uric acid, photostatin C); | — |
Countries
China
Contacts
Public ContactLong Jianfei
Department of Pharmacy, HuaShan Hospital
Outcome results
None listed