Recurrent aphthous ulcer
Conditions
Interventions
experimental group:Oral thalidomide for two months
control group:Nil
Sponsors
Xinhua Hospital Affiliated to Medical College of Shanghai Jiaotong University
Eligibility
Sex/Gender
All
Age
37 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) According to the history and clinical manifestations, the patients were diagnosed as mild to moderate recurrent aphthous ulcer; (2) The age was 18-70 years old, with no gender limit; (3) Blood routine examination, liver function (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, total bilirubin, direct bilirubin), renal function (creatinine, urea nitrogen), electrolytes (k, Na, CL), blood glucose and coagulation were basically normal; (4) There were at least 2 recurrent aphthous ulcer cases with a history of more than 1 year, and oral ulcer occurred more than once a month. (December 2000, trial criteria for efficacy evaluation of recurrent aphthous ulcer) issued by oral mucosal disease Committee of Chinese Stomatological Association; (5) During the treatment, the patients did not receive any other drug treatment other than the scheme; (6) The patients participated voluntarily, signed informed consent and provided personal history. They could take part in the trial review on time and complete the whole research step.
Exclusion criteria
Exclusion criteria: (1) Women of childbearing age; (2) Patients with serious systemic diseases and tumors; (3) Those who are allergic to the drugs or allergic constitution in this study; (4) Alcohol addicts (drinking more than 15 units per week, each unit refers to 350ml beer or 150ml wine or 50ml spirits), smokers, drug abusers, drug abusers and smokers; (5) The subjects used analgesics within 24 hours, antibiotics and anti-inflammatory drugs within 1 month, glucocorticoids and immunosuppressants within 3 months; (6) Any mental illness, or any other illness that can lead to a legally recognized limitation of capacity; (7) Failure to follow the doctor's advice or incomplete records of the trial process affect the judgment of curative effect; (8) Patients with other confirmed oral mucosal diseases; patients with periodontitis; (9) Autoimmune diseases such as Behcet's disease, peptic ulcer, anemia, Crohn's disease, acute infectious diseases, etc; (10) According to the judgment of the researcher, those who are less likely to join the group (such as weak body, significantly overweight, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intermittent period of ulcer attack ; | — |
Countries
China
Contacts
Public ContactLin Ling
Department of Stomatology, Xinhua Hospital Affiliated to Medical College of Shanghai Jiaotong University
Outcome results
None listed