Infectious keratitis
Conditions
Interventions
experimental group:keratoplasty was performed using the biologic keratoprothesis
Sponsors
Wenzhou Medical University Eye Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The lesion of infectious keratitis involves the corneal stroma; 2. Preoperative best corrected visual acuity < 0.05; 3. Age 18-80 years old, regardless of gender.
Exclusion criteria
Exclusion criteria: 1) Patients with severe heart, liver or kidney diseases; 2) Patients with serious blood or endocrine diseases; 3) Patients with mental disorders; 4) Patients with other diseases that affect vision; 5) Corneal perforator; 6) Corneal burns or chemical injuries; 7) Severe corneal neovascularization caused by corneal diseases; 8) Severe dry eye; 9) Incomplete eyelid closure; 10) Patients with severe allergies and/or allergies to the biological amnion; 11) Unable to accept materials of pig origin; 12)Pregnant women, lactating women, or women planning to become pregnant within 1 year; 13) Patients were not considered suitable by the investigator to participate in this clinical trial or had participated in any other clinical trial within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| best corrected visual acuity;Eye irritation symptoms;The transparency of the keratoprothesis;Corneal epithelium healing;The edema of the keratoprothesis;The dissolution and exfoliation of the keratoprothesis;Neovascularization of the keratoprothesis;vision rehabilitation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Conjunctival congestion;Ciliary congestion;Anterior chamber floats;Intraocular pressure; | — |
Countries
China
Contacts
Public ContactWei Chen
Wenzhou Medical University Eye Hospital
Outcome results
None listed