superficial corneal defects
Conditions
Interventions
Experimental group ("wet" biological amnion group):The experimental group received the "wet" biological amnion produced by Guangzhou Youshiqing Biotechnology Co., LTD.
Control group ("dry" biological amnion group):The control group received the "dry" biological amnion produced by Jiangxi Ruiji Biological Engineering Technology Co., LTD.
Sponsors
Wenzhou Medical University Eye Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients from the age of 18 to 65 years with superficial corneal injury caused by surgical wound, thermal burn, chemical injury and keratitis.
Exclusion criteria
Exclusion criteria: 1) Patients with severe heart, liver or kidney diseases; 2) patients with serious blood or endocrine diseases; 3) patients with mental disorders; 4) the primary disease was fungus or acanthamoeba infection; 5) deep stromal layer of cornea defect (defect depth greater than 1/3 corneal thickness); 6) patients with severe dry eye or chemical burns with limbal ischemia in excess of 1/4 quadrant; 7) patients with severe allergies and/or allergies to the biological amnion; 8) patients were not considered suitable by the investigator to participate in this clinical trial or had participated in any other clinical trial within 3 months. 9)pregnant women, lactating women, or women planning to become pregnant within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the repair efficiency of superficial corneal injury at 21 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| amniotic membrane in position;corneal defect area;corneal fluorescein sodium staining;eye irritation symptoms;Best corrected vision ;corneal vascular proliferation;conjunctival congestion;ciliary congestion; | — |
Countries
China
Contacts
Public ContactWei Chen
Wenzhou Medical University Eye Hospital
Outcome results
None listed