T/NK-cell lymphoma
Conditions
Interventions
experimental group:Azacitidine plus chidamide
Sponsors
Anhui Provincial Cancer Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Patients with T/NK cell non-Hodgkin lymphoma confirmed by pathology. 2.70 years old and older at the first diagnosis or more than 60 years old and ECOG 2-4 (man and woman). 3.Relapsed and refractory patients must have received at least one systemic chemotherapy regimen. 4.There is at least one imaging measurable lesion (defined by NHL Lugano staging). 5.Able to understand the purpose and risks of the research, and provide signed and dated informed consent and authorization to use protected health information.
Exclusion criteria
Exclusion criteria: 1. Any other histological type of lymphoma. a. Any history of cancer during the last 5 years with the exception of non-melanoma skin tumors or stage 0 (in situ) cervical carcinoma. b. Any history of treated or non-treated indolent lymphoma. 2. Central nervous system or meningeal involvement by lymphoma. 3. Major surgical procedures were performed within 14 days of treatment of DLBCL. 4. Severe and uncontrolled cardiovascular disease. 5. Poor bone marrow reserve as defined by neutrophils 2 fold ULN). 7. Poor hepatic function (total bilirubin level> 2 fold ULN, transaminases> 3 fold ULN) unless these abnormalities are related to the lymphoma. 8. Uncontrolled and active systemic fungi, bacteria, viruses or other infections. 9. HIV infection. 10. Uncontrolled and active HBV and HCV infection. 11. Situations that investigator found it inappropriate to join this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS;best ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| ORR;PFS;OS;security; | — |
Countries
China
Contacts
Public ContactDing Kai-Yang
JiangSu Province Hospital
Outcome results
None listed