hereditary ovarian cancer
Conditions
Interventions
Gold Standard:Pathological diagnosis
Index test:TnCA125
Sponsors
Obstetrics & Gynecology Hospital of Fudan University
Eligibility
Sex/Gender
Female
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Age: 30-60 years; 2) With hereditary ovarian cancer susceptibility gene harmful mutations: BRCA1, BRCA2, BRIP1, PALB2, RAD51C , RAD51D, BARD1, MSH2, MSH6, MLH1, PMS2, EPCAM; 3) Have at least one ovary or fallopian tube; 4) Able to follow the research protocol and follow up on schedule; 5) Signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Have a personal history of ovarian cancer, including low malignant potential cancers (LMP), or primary papillary serous carcinoma of the peritoneum; 2) Have received preventive salpingo-oophorectomy (RRSO); 3) Participating in other early screening tests for ovarian cancer; 4) have a history of any medical conditions that would place the subject at risk related to phlebotomy, including but not limited to hemophilia or other bleeding disorders, chronic infectious disease, emphysema or serious anemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;specificity;positive predictive value;negative predictive value; | — |
Countries
Cinia
Contacts
Public ContactKang Yu
Obstetrics & Gynecology Hospital of Fudan University
Outcome results
None listed