Breast Cancer
Conditions
Interventions
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM
Eligibility
Sex/Gender
Female
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. All patients were meet the pattern identification criteria of TCM and diagnostic criteria of western medicine; 2. Patients must be postmenopausal female; 3. Aged from 45 to 75 years; 4. Pathological investigations confirmed a primary invasive breast cancer; 5. According to the pathological results and the physical condition, all patients were required to take AI with breast cancer guidelines of CBCSG (version 2019); 6. Patients who have taken AI for at least three months ; 7. Patients who have joint pains during taking AI and the score about BPI-SF > 4; 8. Be willing to participate in clinical trials and be able to cooperate with regular follow-up; 9. All patients must have signed and dated an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Recurrent and metastatic breast cancer; 2. Severe liver and kidney dysfunction (AST/SGOT or ALT/AGPT is > 2.5 times of the ULN, and Serum Cr is >= 150umol/L); 3. Severe heart dysfunction other organ failure; 4. Any previous or concurrent primary malignancy; 5. A history of fracture or joint surgery within 6 months; 6. Patients who had used traditional Chinese medicine, moxibustion treatment or other TCM related treatment for AIA in the past 3 months; 7. Participating in other clinical trials within 3 months; 8. In any reason that cannot cooperate with the study, such as language understanding, unable to refer to the research center, etc.; 9. Other conditions or diseases that may be excluded from the study that may result in significant risk or confusion in the study; 10. Previous use of NSAIDs and opioid analgesics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BPI;bone metabolism;BMP; | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC;electrolytes (Ca, P);sex hormone;To follow the 3-year, 5-year, 10-year disease free survival and overall survival; | — |
Countries
China
Contacts
Public ContactXiaohong Xue
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM
Outcome results
None listed