pediatric brain tumor
Conditions
Interventions
experimental group:Choosing targeted drugs by gene sequencing
Sponsors
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 15 Years
Inclusion criteria
Inclusion criteria: (1) 0-15 years old patients, male or female, patients and their families are willing to participate in this study. Under 18 years of age, signed by the guardians parents. (2) New cases: The history, clinical manifestations, and imaging diagnoses of children with brain tumors. Recurrence cases: The previous surgical history and clinical cases were diagnosed as brain tumors in children, and there are signs of recurrence after conventional treatment. (3) Children who are willing to undergo surgical tumor resection or stereotactic biopsy, can obtain enough tumor samples for molecular diagnosis, and are willing and able to perform continuous monitoring of peripheral blood and cerebrospinal fluid before and after surgery. (4) The KPS score is greater than or equal to 60, and the clinical assessment survival period is greater than 3 months. (5) No use of steroids, or only use less than 2 mg of dexamethasone per day, and the symptoms are stable for more than 5 days. (6) No blood system disease, no bone marrow suppression of 3-4 degrees, good heart, lung, liver, and kidney function, normal lymphocyte count and classification, and no autoimmune disease. (7) No congenital diseases of other organ systems.
Exclusion criteria
Exclusion criteria: (1) Preoperative assessment of tumor resectable probability is low, or postoperative tumor residual is greater than 3*3cm. (2) The child is taking other drugs that may affect the observation in this study, has immunodeficiency disease, or has used steroids greater than 2mg per day. (3) There are ongoing inflammatory diseases in various parts of the body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Partial or complete remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall median survival;Overall median survival; | — |
Countries
China
Contacts
Public ContactMa Jie
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed