obstructive sleep apnea-hypopnea sydrome
Conditions
Interventions
Group 1:Best support control
Group 1:CPAP + BSC
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Pregnant women that agree to participate in the trial and meet all the following conditions: 1. Gestational age between 26 + 0 weeks and 33+ 6 weeks; 2. Diagnosis of pre-eclampsia, gestational hypertension with evidence of preeclampsia, undefined hypertension with proteinuria; 3. No suspicions of major fetal anomaly or malformation (Major fetal anomaly is defined as anomalies or malformations that create significant medical problems for the patient or require specific surgical or medical management. Major anomalies or malformations are not considered a variation of the normal spectrum); 4. Estimated fetal weight by ultrasound >= 500g; 5. Agree for expectant management and standardized care.
Exclusion criteria
Exclusion criteria: Patients that are unwilling to give consent, or present any of the following at presentation: 1. Having a history of eclampsia; 2. Termination of pregnancy at one's own request; 3. Cerebrovascular accident; 4. Severe renal or hepatic impairment presented as creatinine level of greater or equal to 125 µmol/l or liver transaminases greater than or equal to 500 IU/L; 5. Pulmonary edema; 6. Signs of left ventricular failure; 7. Disseminated intravascular coagulation defined as an INR greater than 2; 8. Platelet count at presentation less than 50x10^9; 9. Previous hypersensitivity reaction or contraindications to the use of PPIs; 10. Current use of a drug that may be affected by PPIs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure;sFlt-1;PIGF;24h total urine protein;ALT;AST;Creatinine;Urea Nitrogen;Uric acid;Platelet count; | — |
Countries
China
Contacts
Public ContactHuajun Xu
Shanghai Sixth People's Hospital
Outcome results
None listed