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Relationship between ICSI fertilization rate and male genetic factors in oligoasthenospermia

Relationship between ICSI fertilization rate and male genetic factors in oligoasthenospermia

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000037140
Enrollment
Unknown
Registered
2020-08-27
Start date
2020-10-01
Completion date
Unknown
Last updated
2020-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oligoasthenospermia

Interventions

normal ICSI fertilization rate:no intervention
low ICSI fertilization rate:no intervention

Sponsors

Shanghai First Maternity and Infant Hospital
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
22 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Patients with oligoasthenospermia who underwent ICSI, and had more than 5 million PR sperm; 2. The age of the male was 22-55 years old; 3. The age of the female <= 35 years old.

Exclusion criteria

Exclusion criteria: 1. Female endocrine factors, abnormal ovarian function, genetic factors and adverse pregnancy history were excluded; 2. Male reproductive tract infection, varicocele, hereditary diseases were excluded; 3. The sperm viability was abnormal (eosin staining > 42%); 4. Some special Teratospermia were excluded, such as round headed sperm and pin like sperm; 5. The number of MII eggs obtained for ICSI was less than 5; 6. Patients who have received cancer chemotherapy or radiotherapy, have a history of systemic diseases or related drugs.

Design outcomes

Primary

MeasureTime frame
Gene testing;reproductive system ultrasound;

Countries

China

Contacts

Public ContactFan Yuping

Shanghai First Maternity and Infant Hospital

ralph817@163.com+86 13817025929

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026