Heart failure
Conditions
Interventions
SGLT2i Group:OMT+SGLT-2inhibitor
control group:OMT
Sponsors
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: a. Aged over 18 years; b. The history of chronic heart failure was more than 3 months; c. NYHA grade II-IV; d. Left ventricular ejection fraction (LVEF) >= 50%, no previous record of LVEF 300 pg / ml in patients without a history of atrial fibrillation and > 900 pg / ml in patients with a history of atrial fibrillation); f. Echocardiography showed changes in cardiac structure (left ventricular hypertrophy or left atrial enlargement); g. After informed consent to participate in the clinical trial, and signed a written informed consent.
Exclusion criteria
Exclusion criteria: a. Allergic to any test drug or device; b. Acute heart failure, shock and acute myocardial infarction; c. Patients with severe renal damage (e-GFR less than 30ml / min / 1.73 m2) end stage renal disease or requiring dialysis; d. The patients with pregnancy; e. They are participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| coronary reserve flow, CRF;Coronary microvascular function;Macrovascular function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Compound events of heart failure readmission and all-cause death; | — |
Countries
China
Contacts
Public ContactZhang Li
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed