Cerebral artery dissection
Conditions
Interventions
Gold Standard:Clinical outcome
Index test:The 
model 
for 
based 
on 
gene 
and 
imaging 
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Symptomatic (ischemic stroke or TIA occurring within 2 weeks) patients with intracranial and extracranial arterial or non-stroke patients with asymptomatic; 2. Patients with intracranial and extracranial large (including internal carotid, vertebral, basilar, middle cerebral, etc.), with image support for or probable: (1) Head and neck CTA, TOF MRA/CE MRA or DSA may highly suggest the possibility of arterial if the following signs are present: 1) Beaded or wavy stenosis of blood vessels; 2) Smooth or irregular thinning of blood vessels (typical manifestations are"rat tail sign"and"linear sign"); 3) Obvious vascular intimal flap (valve sign); 4) The blood vessels gradually become thinner to occlusion (typically manifested as"flame sign"); 5) There is double-lumen phenomenon in blood vessels (double-lumen sign); 6) There are double lumens in the blood vessels accompanied by significant rumen dilatation (dissecting aneurysm); (2) HR-MRI evidence of intravascular hematoma and/or intimal flap, except bleeding from atherosclerotic plaques (conditional centers); 3. Agree to obtain blood sample; 4. Voluntarily sign the subject's informed consent form.
Exclusion criteria
Exclusion criteria: 1. Unable to complete imaging (CT or MRI) assessment; 2. Pregnant women; 3. Patients with malignant tumors and other diseases due to the presence of the expected survival of less than 6 months; 4. Patients are receiving experimental drugs and experimental instrument treatment; 5. The doctor believes that it is not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vascular imaging changes: degree of lumen recanalization, intraluminal thrombus, changes in vessel wall signal, etc.;gene expression profiling;SEN, SPE, ACC, AUC of ROC, PPV, NPV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stroke Recurrence;All-cause mortality;Post-stroke disability;Life-threatening bleeding; | — |
Countries
China
Contacts
Public ContactXiang Han
Department of Neurology, Huashan Hospital, Fudan University
Outcome results
None listed