Malignant
Conditions
Interventions
Trial group:Neoantigen vaccines
Control group:Conventional treatment
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 20, <= 75 years old, male or non-pregnant female; 2. Patients with solid tumors at an advanced stage or at high risk of recurrence after resection; 3. No serious underlying diseases; 4. The expected survival period is greater than three months; 5. Pathologically diagnosed as a solid tumor; 6. No significant heart, lung and kidney function, no HIV or syphilis infection; 7. All patients should sign an informed consent form when enrolled.
Exclusion criteria
Exclusion criteria: 1. The general condition before surgery is poor, and it is estimated that the treatment cannot be tolerated 2. Patients with autoimmune diseases; 3. Unstable angina, symptomatic congestive heart failure, severe arrhythmia, myocardial infarction in the past 6 months, prolonged QT interval (>450ms); 4. Malignant tumors in other parts appeared within the last 3 years; 5. The patient cannot be followed up or is participating in other clinical trials; 6. Those who cannot obtain enough tumor tissue samples.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival time;Disease free survival time; | — |
Countries
China
Contacts
Public ContactShiwei Guo
Shanghai Changhai Hospital
Outcome results
None listed