Chronic thromboembolic pulmonary hypertension
Conditions
Interventions
Interventions:Balloon pulmonary angioplasty
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed as CTEPH according to the Chinese guidelines for diagnosis and treatment of pulmonary hypertension (2018 Edition) (1) There were chronic thromboembolic diseases with mean Pap >= 25mmhg in resting state or less than 25mmhg in resting state; (2) Pulmonary ventilation perfusion (VQ) scan pulmonary angiography, computed tomography (CT) pulmonary angiography or magnetic resonance pulmonary angiography (MRPA) confirmed chronic thromboembolic diseases according to diagnostic criteria; 2. Patients who received anticoagulant therapy for more than 3 months before the diagnosis of CTEPH; 3. Patients with CTEPH who are unable to perform pea because of contraindications, have high surgical risk or are unwilling to take pea.
Exclusion criteria
Exclusion criteria: 1. Clinical diagnosis: (1) Pulmonary hypertension caused by other causes other than chronic thromboembolic pulmonary hypertension (CTEPH). (2) At present, there are active infection and sepsis. (3) Hemorrhagic disease, unhealed ulcer. (4) Patients with severe complications, such as liver disease, kidney disease, bleeding tendency, and poorly controlled diabetes and hypertension. (5) The life expectancy is less than 2 years. 2. Laboratory inspection (1) Hematological abnormalities (WBC < 3 x 10^9 / L, acute anemia HB < 90g/L, platelet count < 50 x 10^9). (2) Renal failure (EGFR < 30ml / min * 1.73m ^ 2) and / or advanced renal disease require renal dialysis. (3) Serious infectious diseases. (4) Severe bleeding tendency. 3. Device related (1) Allergy or contraindication to nitinol, iodine contrast agent, aspirin, clopidogrel and heparin. (2) Pregnancy, lactation or planned pregnancy during the trial. (3) The researcher judged that the patient's compliance was poor and could not complete the study according to the requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean pulmonary artery pressure;pulmonary vascular resistance; | — |
Countries
China
Contacts
Public ContactDachun Xu
Shanghai Tenth People's Hospital
Outcome results
None listed