Clinical study of autologous fat glue alone or combined with metformin in the treatment of knee osteoarthritis

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000037081

Enrollment

Unknown

Registered

2020-08-26

Start date

2020-10-01

Completion date

Unknown

Last updated

2020-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Interventions

1:Etoricoxib

2:Etocoxib and metformin 1000mg

3:Etocoxib and metformin 2000mg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male or female aged 35-70 years old; 2. Patients with knee osteoarthritis.

Exclusion criteria

Exclusion criteria: 1. Patients with osteoarthritis whose K-L grade is less than 2; 2. Patients with inflammatory joint diseases (rheumatoid arthritis, psoriatic arthritis, etc.); 3. Patients with any infection, including skin infection, or symptoms and signs of infection or fever. 4. Patients with immune system deficiency, such as diabetes, cancer, AIDS. 5. Patients who need immunosuppressive drugs; 6. Patients with long-term use of NSAIDs; 7. Patients with ipsilateral or contralateral knee surgery history; 8. Patients who are unable to perform MRI examination.

Design outcomes

Primary

Measure	Time frame
Weight;MRI;Methylation;Knee function score;telomerase;	—

Countries

China

Contacts

Public ContactZhang Xiaoling

Xinhua Hospital Affiliated to Medical College of Shanghai Jiaotong University

xlzhang@shsmu.edu.cn+86 13564636096

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026