Schizophrenia
Conditions
Interventions
control group:base diet with olanzapine
Intervention group :ketogenic diet with olanzapine
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-55 years old, male or female; 2. The patients who met the DSM-V diagnostic criteria of schizophrenia; PANSS score >= 60; 3. Patients who have been taking olanzapine for at least 6 months (the dose has not changed within at least 1 month); 4. Patients with other antipsychotics were stable for at least one month; 5. Fasting blood glucose of 6.1-6.9 mmol / L or patients with blood glucose > 7.8 mmol / L and BMI >= 27 kg / m2 in two hours after oral administration of 75g glucose in glucose tolerance test.
Exclusion criteria
Exclusion criteria: 1. Patients with severe digestive, cardiovascular, respiratory, liver and urinary system or genetic metabolic diseases with ketogenic diet taboo (such as complex 2-5 fatty acid metabolic disorder in etc deficiency) and congenital immunodeficiency disease; 2. Patients who are not suitable for ketogenic diet therapy; 3. Patients with type 1 and type 2 diabetes or taking antidiabetic drugs; 4. Patients with impaired liver function (ALT > 2 times the upper limit of normal value); 5. Patients with impaired renal function (creatinine > 150 umol/L); 6. Patients with impaired islet function (acute or chronic pancreatitis); 7. Patients with severe hypertension (systolic blood pressure > 180mmhg, diastolic blood pressure > 100mmhg); 8. Patients taking diet pills; 9. Pregnant or lactating women; 10. Patients with substance abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PANSS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal flora detection;Parameters of glucose and lipid metabolism;RBANS score;Blood biochemical indicators; | — |
Countries
China
Contacts
Public ContactPeng Yanmin
Shanghai Mental Health Center
Outcome results
None listed