Gastric cancer
Conditions
Interventions
Group 1:Roux-en-Y
Group 2:Billroth II+Braun
Group 3:uncut Roux-en-Y
Sponsors
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with age >= 18 years and <= 75 years old; 2. Patients with resectable distal gastric malignant tumor confirmed by PET-CT, abdominal enhanced CT, gastroscopy and pathology, or advanced distal gastric malignant tumor with surgical indications after MDT neoadjuvant / transformation therapy; 3. All patients underwent total laparoscopic distal gastrectomy (D2 lymph node dissection); 4. Patients who voluntarily participate in this study should sign the informed consent form. If the subjects can not read or sign, the informed consent form should be signed by the legal representative under the condition of informed consent of the subjects. For the subjects who are unable to express their consent, the above introduction and explanation should be provided to their legal representatives, and the legal representatives should sign the informed consent form; 5. Patients of childbearing age and their spouses are willing to take contraceptive measures.
Exclusion criteria
Exclusion criteria: 1. Patients with upper gastrointestinal bleeding and tumor perforation need emergency surgical intervention; 2. Patients with previous history of upper abdominal surgery or extensive abdominal adhesions found by laparoscopic exploration; 3. Patients with ASA grade IV; 4. Patients with severe adhesion to surrounding tissues were included in the advanced gastric cancer group, and the MDT; team assessed that they could try open surgery, but could not perform laparoscopic surgery; 5. Patients with severe hematological and immune system diseases or malignant tumors of other tissues and organs; 6. Patients with other serious diseases, including but not limited to: (1) Uncontrollable congestive heart failure (NYHA grade III or IV), unstable angina pectoris, poorly controlled arrhythmia, uncontrolled moderate hypertension (SBP > 160mmhg or DBP > 100mmhg). (2) Active infection. (3) Uncontrolled diabetes. (4) HIV infection. (5) Patients with interstitial pneumonia or low oxygen saturation. (6) Active autoimmune diseases requiring long-term steroid use. (7) Patients who have received allografts. (8) Mental illness affecting informed consent and / or protocol compliance. (9) Severe cirrhosis, bleeding and coagulation dysfunction (INR > 1.3) and peripheral platelet count were significantly reduced < 50x10^9 / L; 7. Patients with serious diseases considered unsuitable for the study by other researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| perioperative complications;Grading of bile reflux under endoscope;Quality of life;Readmitment state within 30 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Two years disease-free survival;Two years overall survival; | — |
Countries
China
Contacts
Public ContactPing Dong
Xinhua Hospital afflicted to Shanghai JiaoTong University School of Medicine
Outcome results
None listed