drug-induced liver injury
Conditions
Interventions
Sponsors
Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Prospective follow-up cohort of liver injury caused by tripterygium wilfordii preparation combined with different Western medicine: (1) patients with rheumatoid arthritis (ra) basic diseases, one of the admission diagnosis of drug-induced liver injury "" or" drug-induced liver disease "or" drug-induced hepatitis "or" drug-induced liver damage "or" drug cirrhosis "or" drug-induced liver failure or use other diagnostic terminology hints may be an various types of drug-induced liver injury patients, diagnostic criteria, meet above drug-induced liver injury and causation RUCAM score of 3 or more cases; (2) No limitation on age and gender; sign informed consent. Clinical study on DILI induced by immunocheckpoint inhibitor combined with Traditional Chinese medicine: (1) basic diseases of liver cancer patients, the hospital diagnosis of drug-induced liver injury "" or" drug-induced liver disease "or" drug-induced hepatitis "or" drug-induced liver damage "or" drug cirrhosis "or" drug-induced liver failure or use other diagnostic terminology hints may be an various types of drug-induced liver injury patients, diagnostic criteria, meet above drug-induced liver injury and causation RUCAM score of 3 or more cases; (2) No limitation on age and gender; sign informed consent.
Exclusion criteria
Exclusion criteria: Prospective follow-up cohort of liver injury caused by tripterygium wilfordii preparation combined with different Western medicine: (1) The possibility of drug-induced liver injury has been clearly excluded at the time of discharge diagnosis of various types of liver injury; (2) Patients with incomplete clinical key data, unable to make clinical judgment on DILI diagnosis or unable to use RUCAM scale for causal assessment; (3) Liver damage caused by exposure to toxic chemicals; (4) Patients with liver injury combined with other factors such as virus, immunity, alcohol, genetic metabolism, bile duct, blood vessel, etc.; (5) Non-rheumatoid arthritis patients. Clinical study on DILI induced by immunocheckpoint inhibitor combined with Traditional Chinese medicine: (1) The possibility of drug-induced liver injury has been clearly excluded at the time of discharge diagnosis of various types of liver injury; (2) Patients with incomplete clinical key data, unable to make clinical judgment on DILI diagnosis or unable to use RUCAM scale for causal assessment; (3) Liver damage caused by exposure to toxic chemicals; (4) Patients with liver injury combined with other factors such as virus, immunity, alcohol, genetic metabolism, bile duct, blood vessel, etc.; (5) Non-liver cancer patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| outcoms related to viral hepatitis A;outcoms related to viral hepatitis B;outcoms related to viral hepatitis C;outcoms related to viral hepatitis D;outcoms related to viral hepatitis E;autoantibody;immune globulin;liver biochemical;Renal biochemical;blood routine examination;routine urine test;B-mode ultrasound;ECG; | — |
Countries
China
Contacts
Public ContactLiu Chenghai
Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed