sepsis acute kidney disease
Conditions
Interventions
control group:CRRT
experimental group:CRRT+HP
Sponsors
Shanghai Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Aged >= 18 years; 2) In line with the definition of sepsis in the 2016 campaign to save sepsis (SSCM). Sepsis was defined as infection (microbial culture basis) + organ dysfunction (sofa) >= 2 points; 3) The AKI diagnostic criteria of 2012 KDIGO guidelines were met; 4) Has received standard treatment including fluid resuscitation, vasoactive drugs, antibiotics, respiratory support, nutritional support, vital signs monitoring, etc. (according to the 2016 SSCM guidelines); 5) Patients and their family members were informed and voluntarily participated in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1) The written consent of the patient or client cannot be obtained; 2) Patients who were pregnant or suspected of pregnancy or lactation at the time of inclusion; 3) Organ transplant recipients within one year; 4) Those who have been in ICU in recent 28 days; 5) Patients with extensive metastasis of malignant tumor; 6) End stage renal disease requiring maintenance dialysis; 7) Patients with acute myocardial infarction in the past 4 weeks; 8) Patients with uncontrollable bleeding (acute hemorrhage > 3upc in the past 24 hours); 9) Patients with severe leukopenia (< 0.5 x 10^9 / L) or severe thrombocytopenia (< 30 x 10^9 / L); 10) Patients allergic to hemoperfusion and filter; 11) Anticoagulant allergy; 12) In any other case, the researcher thinks that it is not suitable to participate in this study, such as: the terminal state of chronic disease, and there is no possibility of survival or discharge.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 day mortality; | — |
Countries
China
Contacts
Public ContactNiansong Wang
Shanghai Sixth Hospital
Outcome results
None listed