non-small lung cancer cell, NSCLC
Conditions
Sponsors
LongHua Hospital, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Those who met the diagnostic criteria of primary bronchogenic carcinoma and were diagnosed as lung squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma and large cell carcinoma by pathology or cytology; (2) After conventional platinum chemotherapy, according to RECIST 1.1, the patient suffered from radiologic disease progression determined by the researcher; (3) After EGFR/ALT-TKIs treatment, according to RECIST 1.1, the patient had the progression of radiologic disease as determined by the investigator; (4) TCM syndrome differentiation belongs to Qi and yin deficiency, lung and kidney essence deficiency, phlegm and toxin accumulation type; (5) Aged >= 18 years; (6) The expected survival time was more than 3 months; (7) Blood routine test, liver and kidney function, electrocardiogram were basically in the normal range; (8) Volunteer to participate in clinical research and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients receiving concurrent radiotherapy, chemotherapy and targeted therapy; (2) They have been treated with anti-PD-1, anti-PD-L1 or anti-PD-L2 drugs. (3) Patients with interstitial pneumonia and poor lung function; (4) People with autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and psoriasis; (5) Those who have undergone organ and hematopoietic stem cell transplantation; (6) Pregnant or lactating patients; (7) Patients with mental history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression-free survival, PFS;median survival time, MST; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease Control Rate, DCR;Duration of disease control, DDC;Immune indicators;Quality of life;Security indicator; | — |
Countries
China
Contacts
Public ContactJia Yang
LongHua Hospital, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed