birth defect
Conditions
Interventions
Gold Standard:NIPT
Index test:HLPA 
technology 
was 
used 
to 
the 
of 
21, 
18, 
and 
X 
in 
Sponsors
International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong university
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: (1) Prenatal screening (such as serological screening and imaging examination) indicates critical risk of common chromosome aneuploidy (i.e., down's screening risk value is 1/270-1/1000, trisomy 18 and Trisomy 13 risk value is 1/350-1/1000); (2) There are contraindications to interventional prenatal diagnosis (threatened abortion, fever, infection, etc.); (3) Patients with large gestational age and missed the serological screening time but hoped to reduce the risk of common aneuploidy.
Exclusion criteria
Exclusion criteria: (1) Multiple pregnancies; (2) The pregnant woman is a patient with chromosomal abnormalities; (3) The pregnant woman has invasive surgery experience on the day of blood drawing; (4) The pregnant woman has received allogeneic blood transfusion, transplantation surgery, stem cell therapy and other experiences; (5) Reject the cffDNA tester.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 21, 18, 13 trisomy and X monomer risk; | — |
Countries
China
Contacts
Public ContactChenming Xu
International Peace Maternity and Child Health Hospital
Outcome results
None listed