Critical brain injury
Conditions
Interventions
Trial group 1:PHGG
Trial group 2:PHGG+Lostridium Butyricum
Trial group 3:TP+Lostridium Butyricum
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. ICU patients who meet the definition of critical brain injury, and expected to stay in ICU >=12 days; 2. 18-80 years old (including boundary value); 3. AGI grade I or II at ICU admission; 4. Hemodynamic stability: 1) Mean arterial pressure MAP (mean arterial pressure) >= 65 mmHg; 2) No vasoactive drugs or low-dose vasoactive drugs: norepinephrine <0.5µg/kg/min, dopamine infusion < 5µg/kg/ min (or norepinephrine equivalent price formula: (norepinephrine <12.5µg/ min = [norepinephrine (µg/ min)) + [dopamine (µg/ kg / min) ÷ 2] + [adrenal gland (Mg/min)] + [Phenylephrine (µg/min)÷10] + [vasopressin (Unit/h)×8.33]); 5. Unable to eat through the mouth, and initiating total nutritional enteral nutrition support is required and a nasointestinal or nasogastric tube can be safely established; 6. The informed consent is signed, and the questionnaire survey and follow-up need to be completed as required.
Exclusion criteria
Exclusion criteria: 1. Enteral nutrition products containing dietary fiber and whole nutrient were received within 24 hours before ICU admission; 2. Patients with known presence of inflammatory bowel disease (Crohn's disease or ulcerative colitis); 3. Patients who are undergoing chemotherapy and radiation; 4. Patients who recieved bone marrow or organ transplant; 5. HIV positivity; 6. Pregnant or lactating woman; 7. A history of galactosemia; 8. Patients who are known to be allergic to any of the ingredients in the test products or who have been identified by researchers as needing to limit their dietary fiber intake; 9. Other patients considered not suitable for this study by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in gut microbiota;Organ function evaluation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Targeted feeding rate;Blood glucose during ICU stay;Changes of hemoglobin, prealbumin, and quadriceps femoris thickness (QMLT) before and after 10 days of enteral nutrition support;28 days mortality after ICU admission;Length of hospital stay;Length of hospital stay;Length of ICU stay;Inflammation levels; | — |
Countries
China
Contacts
Public ContactTan Jiaying
Huashan Hospital, Fudan University
Outcome results
None listed