A clinical study on the enhancement of working memory in aMCI patients based on the optimized rTMS scheme of frontal-parietal functional connection

A clinical study on the enhancement of working memory in amnestic Mild Cognitive Impairment(aMCI) patients based on the optimized repetitive transcranial magnetic stimulation(rTMS) scheme of frontal-parietal functional connection

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000036913

Enrollment

Unknown

Registered

2020-08-25

Start date

2020-10-01

Completion date

Unknown

Last updated

2020-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amnestic Mild Cognitive Impairment(aMCI)

Interventions

HF rTMS group (maybe non-response aMCI), I A group:HF rTMS

Optimized rTMS group (maybe non-response aMCI), I B group:Optimized rTMS

Sham rTMS group (maybe non-response aMCI), I C group:Sham rTMS

HF rTMS group (maybe response aMCI), II A group:HF rTMS

Optimized rTMS group (maybe response aMCI), II B group:Optimized rTMS

Sham rTMS group (maybe response aMCI), II C group:Sham rTMS

Eligibility

Sex/Gender

All

Age

50 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Right-handed, 50-85 year old Chinese; 2. Voluntary signing of informed consent; 3. Patients diagnosed with aMCI.

Exclusion criteria

Exclusion criteria: 1. Have severe visual, hearing, aphasia and other physical diseases and cannot successfully complete the neuropsychological test; 2. Have a history of other neurological or psychiatric disorders (such as dementia, stroke, Parkinson's disease, epilepsy, major depression, etc.), cardiovascular disease, diabetes, thyroid disease, vitamin B12 deficiency, history or evidence of substance abuse; 3. Any drug history that may affect cognitive function in the past 1 month; 4. Have contraindications with MRI scanning; 5. Structural MRI indicated lesions such as new lesions or space-occupying lesions.

Design outcomes

Primary

Measure	Time frame
Working memory;Event related potential (ERP): N2PC, CDA;	—

Secondary

Measure	Time frame
Neuropsychological test battery;	—

Countries

China

Contacts

Public ContactYunxia Li

Department of Neurology, Tongji Hospital, Tongji University School of Medicine

doctorliyunxia@163.com+86 13636370312

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026