Adverse reactions during endotracheal intubation and extubation
Conditions
Interventions
experimental group:Local anesthesia is performed through a spray tracheal tube
control group:Common tracheal
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age from 18 to 75 years old, regardless of gender; 2. Patients diagnosed with craniocerebral or spinal tumors are scheduled to undergo general anesthesia for tumor resection; 3. Body mass index (BMI) measure of 18.5 kg/m2 < BMI <= 30 kg/m2; 4. ASA classification is I–III; 5. The informed consent shall be agreed and signed by the ETHICS Committee.
Exclusion criteria
Exclusion criteria: 1. The heart, kidney, liver and other important organs function is not complete; 2. Respiratory dysfunction; 3. Prior use of beta blockers, digoxin, alpha agonists or psychotropic drugs; 4. Heart rate less than 60 times/min or blood pressure less than 100/60mmhg; 5. Previous history of allergy; 6. II or III-degree atrioventricular block; 7. Pregnant/lactating women; 8. Morbidly obese people.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A comprehensive assessment of adverse events during intubation and extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cortisol;Extubation time; | — |
Countries
China
Contacts
Public ContactYuan Lan
Department of Anesthesiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed