Kawasaki Disease
Conditions
Interventions
Gold Standard:Meet the diagnostic criteria established by the American Heart Association (AHA) in 2017:
Fever lasts for 5 days or more, excluding other infectious diseases with similar manifestations
Extremities:
Acute hard swelling of hands and feet, and desquamination of toe ends in convalescence
Pleomorphic rash
(4) Bilateral bulbous 
miR-125a-5p, 
Sponsors
Shanghai Children's Hospital, Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
1 Years to 14 Years
Inclusion criteria
Inclusion criteria: KD group: The KD children met the diagnostic criteria established by the American Heart Association (AHA) in 2017: (1) Fever lasts for 5 days or more, excluding other infectious diseases with similar manifestations; (2) Extremities: Acute hard swelling of hands and feet, and desquamination of toe ends in convalescence; (3) Pleomorphic rash; (4) Bilateral bulbous conjunctiva hyperemia without exudative changes; (5) Changes in the lips and mouth: chapped lips, arbutus tongue, mouth and throat mucosal diffuse congestion; Cervical lymph node enlargement (diameter > 1.5 cm), usually on one side; Among them, fever lasting for 5 days or more is the necessary condition, meeting at least 4 of the other 5 criteria, and excluding other diseases, KD can be confirmed.KD can also be diagnosed on day 4 when at least 4 clinical criteria are present. Inclusion criteria for the fever control group: respiratory infectious diseases or other febrile diseases such as scarlet fever, juvenile idiopathic arthritis, etc.
Exclusion criteria
Exclusion criteria: Children with a history of Kawasaki disease were excluded, including cardiovascular diseases and autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| miRNA; | — |
Countries
China
Contacts
Public ContactChen Liqin
Shanghai Children's Hospital
Outcome results
None listed