Acute Respiratory Distress Syndrome
Conditions
Interventions
Case series:none
Sponsors
Shanghai Children's Hosptial
Eligibility
Sex/Gender
All
Age
0.1 Years to 14 Years
Inclusion criteria
Inclusion criteria: (1) Children are diagnosed as refractory hypoxic respiratory failure /ARDS in PICU. The diagnostic criteria for refractory hypoxic respiratory failure is that the development of respiratory failure could not be prevented by pulmonary protective ventilation strategy, conservative fluid management, prone position, neuromuscular junction blockers, etc. PaO2/FiO2 1hr), (4)Or shock VIS > 100 [vasoactive drug index (VIS)=100 x adrenal (ug/kg.min)+100x norepinephrine (ug/kg.min)+10x milrinone(ug/kg.min)+1x dopamine (ug/kg.min)+1x dobutamine (ug/kg.min)] (VIS reference for measurement [Gaies MG, Gurney JG, Yen AH, Et al. Vasoactive-inotropic Score as a predictor of mortality in infants after cardiopulmonary bypass, 2010,11:234-238), or pediatric patients with combined blood lactate >4 mmol/L, or Cardiopulmonary resuscitation (CPR); (4) CRRT indications: patients with acute kidney injury (AKI) treated with diuretics had urine volume 10%, or hemodynamic instability with severe pulmonary edema (LUS score >15); (5) The age of the patient was from January to 14 years old; (6) Sign informed consent.
Exclusion criteria
Exclusion criteria: (1) With severe intracranial hemorrhage and cerebral functional failure; (2) Children with stem cell transplantation; (3) Tumor and leukemia combined with severe hypoxic respiratory failure, expected survival time <2 years; (4) Patients who discontinued ECMO treatment due to non-medical factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| ECMO withdrawal success rate;60-Day survival rate;Length of PICU stay;Duration of mechanical ventilator;Organ function index; | — |
Countries
China
Contacts
Public ContactYucai Zhang
Shanghai Children's Hospital
Outcome results
None listed