metastatic squamous cell carcinoma
Conditions
Interventions
Index test:Immunohistochemistry, 
p16, 
in 
situ
Sponsors
Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years old; 2. Participants (or their legal representatives/guardians) must sign an informed consent form for sample collection. 3. It is derived from a primary or metastatic sample with a clear primary tumor, and it is clearly diagnosed as SCC by pathology. 4. Fresh samples are stored in gas phase liquid nitrogen, and paraffin samples are routinely stored. 5. There is enough tissue to extract 1000 µg of protein and at least 20 µg of DNA and RNA at the same time. 6. A representative paraffin-embedded H&E section that matches the case, or a digital image of a H&E-stained section of the entire section from the original anatomical pathological diagnosis of the tumor and confirmed to be cancer. 7. The cellular components of the tumor sample must be known or can be determined. The specific requirements are as follows: (1) Each tumor sample is mainly composed of live tumor cells in histology; (2) The proportion of tumor cell nuclei in the sample >=80%; (3) The proportion of normal matrix, inflammatory or immune cells =200mg; (3) In the area of the entire tissue section, at least 50% of the area is composed of viable cells (tumor or other cells, not extracellular matrix).
Exclusion criteria
Exclusion criteria: 1. Incomplete medical history information; 2. Failed to sign the informed consent form; 3. Pathological diagnosis is unknown; 4. The sample size is not enough for multi-omics detection of gene and protein; 5. The investigator believes that the patient should not be included in other conditions in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene Expression; | — |
Countries
China
Contacts
Public ContactXu Midie
Fudan University Shanghai Cancer Center
Outcome results
None listed