mild cognitive impairment
Conditions
Sponsors
Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of TCM
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male and female participants aged >= 60 years; 2. Clear consciousness, normal hearing and visual abilities are maintained, and have the ability to participate in the neuropsychological activity test; 3. Participants meet diagnostic criteria for MCI in ICD-10 and should meet the following items at the same time: 1) The patient or insider subjectively feels that there is a decline in cognitive function; 2) Impaired cognitive function in objective examination; 3) The daily life function is basically normal; 4. It does not meet the diagnostic criteria of Dementia; The total score of Clinical Dementia Rating Scale (CDR) Chinese version was 0.0 to 0.5; 5. The total score of Montreal Cognitive Assessment (MoCA) Beijing version is below 26 (years of education < 12 years, MOCA score < 25); 6. Participants agree to sign the informed consent form and volunteer for this study.
Exclusion criteria
Exclusion criteria: (1) Participants with a history of mental disorders such as dissociative disorder, obsessive-compulsive disorder, personality disorder, schizophrenia, bipolar disorder, severe depression disorder, anxiety disorder are excluded; (2) Participants with a history of drug or alcohol dependence or drug allergies are excluded in this study; (3) Participants were taking antipsychotic medication or medications that affect cognition; (4) Participants with a history of head trauma resulting in loss of consciousness; (5) Any participant on treatment were withdrawn from other clinical drug trials before the first study-drug administration were less than 4 weeks. (6) Participants with serious gastrointestinal diseases (such as indigestion, gastrointestinal obstruction, gastroduodenal ulceration) and serious secondary diseases that affect drug absorption; (7) Participants comprised hepatic and renal dysfunctionsevere neurological diseasescardiovascular and cerebrovascular diseases complication as well as a history of other autoimmune diseases and any other contraindication; (8) Participants with scores of the 30-item version of the Geriatric Depression Scale (GDS-30) higher than 20. (9) The Hamilton Anxiety Rating Scale (HAMA14-item version) score of >= 21 points.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA;MES; | — |
Secondary
| Measure | Time frame |
|---|---|
| FAQ;Record cognitive event-related potential ERP;Detection of homocysteine; | — |
Countries
China
Contacts
Public ContactXu Jian
Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of TCM
Outcome results
None listed