Gastroesophageal reflux disease
Conditions
Interventions
Sponsors
Shanghai Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The research content 1 1.Inclusion criteria for subjects with refractory gastroesophageal reflux disease A. Meet the diagnostic criteria of gastroesophageal reflux disease; B. Eight weeks of standard PPI treatment for failure with gastroesophageal reflux disease prior to this study; C. Between the ages of 18 and 65, regardless of gender; D. The patient is informed and signs the informed consent. 2.Inclusion criteria for healthy subjects: A. Healthy volunteers who had physical examination in our hospital; B. Between the ages of 18 and 65, regardless of gender; C. The patient is informed and signs the informed consent. The research content 2 A. It meets the diagnostic criteria of gastroesophageal reflux disease. B. Patients who had failed to treat gastroesophageal reflux disease with standard dose PPI for 8 weeks prior to this study.
Exclusion criteria
Exclusion criteria: The research content 1 A. Patients with one of the following diseases: peptic ulcer, history of gastroesophageal and duodenal surgery, Zo-AIDS syndrome, primary esophageal motional diseases (such as achalasia of cardia, scleroderma, primary esophageal spasm), malignant lesions of upper digestive tract, coronary heart disease, diabetes, drug esophagitis. B. Pregnant or lactating women, C. Allergic constitution and psychosis. D. The patient was a researcher directly involved in this clinical study. E. Simultaneous use of drugs that may affect the efficacy and safety of drugs. F. It was considered that there were any circumstances unsuitable for inclusion in the study. The research content 2 A. Patients with one of the following diseases: peptic ulcer, history of gastroesophageal and duodenal surgery, Zo-AIDS syndrome, primary esophageal motional diseases (such as achalasia of cardia, scleroderma, primary esophageal spasm), malignant lesions of upper digestive tract, coronary heart disease, diabetes, drug esophagitis. B. Pregnant or lactating women, C. Allergic constitution and psychosis. D. The patient was a researcher directly involved in this clinical study. E. Simultaneous use of drugs that may affect the efficacy and safety of drugs. F. It was considered that there were any circumstances unsuitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metagenome of intestinal flora;Macroproteome of intestinal flora;Electronic gastroscope;Clinical symptom observation table;Quality of Life Rating scale; | — |
Countries
China
Contacts
Public ContactSun yongshun
Shanghai Traditional Chinese Medicine Hospital
Outcome results
None listed