immature root with apical periodontitis
Conditions
Interventions
the experimental group:BMSCs implant
Sponsors
The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
14 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1) immature permanent teeth with single root canal. 2) no need for crown restoration in a short term.
Exclusion criteria
Exclusion criteria: 1) The root of the tooth is almost complete, and the diameter of the apical hole is less than 1mm. 2) Root fracture. 3) Patients with a heavy history of drug allergy. 4) Patients with a pacemaker who cannot undergo the pulp vitality test. 5) Patients who are unwilling to undergo X-ray examination due to birth planning or other reasons during the observation period. 6) Poor nutritional condition (serum albumin concentration <2 g/dL). 7) Other systemic disease History of hereditary disease. 8) The oral hygiene maintenance is not well done, and the follow-up cannot be conducted in time during the observation period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensation in the BMSCs-implanted teeth, as assessed by electric pulp vitality tests;Formation of sensory nerves and blood vessels, as indicated by histological analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Increased length of the root based on CBCT analysis;Decreased width of apical foramen based on CBCT analysis; | — |
Countries
China
Contacts
Public ContactJia Wang
Shanghai Ninth People's Hospital affiliated with Shanghai Jiao Tong University, School of Medicine
Outcome results
None listed