Septic Shock
Conditions
Interventions
control group:Conventional treatment
Esmolol 72 hours treatment group:Esmolol titration treatment 72 hours
Esmolol continuous treatment group:Esmolol continuous titration treatment until the patient discharged/died/transferred out of ICU
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) In accordance with SCCM and ESICM issued sepsis 3.0 definition and diagnostic criteria for the diagnosis of septic shock: sepsis with blood pressure, after appropriate volume resuscitation, still need vasopressors to maintain MAP >= 65 mmHg and serum lactic acid level > 2 mmol/L. 2) HR > 100 bpm after 24 hours standard treatment.
Exclusion criteria
Exclusion criteria: 1) Aged < 18 years; 2) Acute left heart failure or chronic heart failure, NYHA cardiac function class III and above; 3) After appropriate volume resuscitation, CI<2.0 L/min/m2; 4) Long-term use of beta blockers; 5) With severe asthma, chronic obstructive pulmonary disease (COPD), atrioventricular block II degrees or more; 6) Pregnant women; 7) Refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 day mortality;Hemodynamic parameters;Dose of Norepinephrine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood lactate level;Indicators of blood inflammation;APACHE?;SOFA;Total mechanical ventilation time;Length of ICU stay; | — |
Countries
China
Contacts
Public ContactYuanzhuo Chen
Shanghai Tenth People's Hospital
Outcome results
None listed