Thrombotic disorders of pregnancy
Conditions
Interventions
Control group:Blood samples were drawn to detect anti XA factor and coagulation index, and the drugs were used empirically
experimental group:Blood samples were drawn to detect anti XA factor and coagulation index, and the dosage was adjusted according to the dose adjustment table
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1) The degree of venous thromboembolism was 0-III grade. 2) Pregnant women who are healthy before pregnancy, singleton. 3) The age was 18-45 years old and the gestational age was 34-40 weeks. 4) The detection range of atiiii is 70% - 130%. 5) Informed consent signed by patients.
Exclusion criteria
Exclusion criteria: 1) Severe active bleeding (brain, digestive tract, urinary system or other parts); 2) High risk pregnancy; 3) Primary hypertension, diabetes, intrauterine infection, heart disease; 4) Patients with severe liver and kidney insufficiency, blood diseases and autoimmune diseases; 5) Chronic consumptive disease, lower limb paralysis or acute spinal cord injury, abnormal lipid metabolism; 6) Patients who have taken drugs interfering with fibrinolysis and coagulation in recent 2 weeks; 7) Incomplete clinical data; 8) Drop out of the study; 9) Cerebrovascular events (cerebral infarction, cerebral hemorrhage) occurred within 3 months; 10) Severe bleeding and coagulation dysfunction; 11) Liver failure; 12) History of abortion; 13) Combined with peptic ulcer, gastrointestinal malignant tumor, intracranial tumor; 14) Hypertension patients without good control: systolic blood pressure >= 180 mmHg, diastolic blood pressure >= 110 mmHg 15) The patient is allergic to the test drug; 16) The patient has a history of alcoholism / drug abuse; 17) Combined use of other anticoagulant drugs or drugs with influence on anticoagulant drug metabolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anti XA factor;Coagulation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy complications;Pregnancy outcome; | — |
Countries
China
Contacts
Public ContactXie Hongjuan
Shanghai First Maternity and Infant Hospital
Outcome results
None listed