Alzheimer's Disease
Conditions
Interventions
case series:Nil
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age ranges from 55 to 80; males and females; 2. Medication: Not taking anti-dementia and cognitive improvement drugs systematically; 3. Clinical Dementia Rating (CDR)scale =0.5; Diagnostic criteria for MCI: (1) cognitive impairment reported by patients or insiders, or discovered by experienced clinicians; (2) There is objective evidence of impairment in one or more cognitive function domains (from cognitive tests); (3) Complicated instrumental daily ability can be slightly impaired, but independent daily ability maintained; (4) The diagnosis of dementia has not yet been reached; Mild AD meets NIA-AA diagnostic criteria (CDR=1): (1) impaired work or daily activities; (2) Life function and executive ability decline than previous levels; (3) Cannot be explained by delirium or other serious psychiatric disorders; (4) Cognitive disorders are discovered and diagnosed based on medical history collection and objective cognitive evaluation; (5) Cognitive or behavioral impairment includes at least two aspects: learning and remembering new information; reasoning and processing complex tasks and judgment; visual space ability; language function (speaking, reading, writing); personality or behavior changes. And has the following characteristics: (1) insidious onset; (2) a clear history of cognitive deterioration is reported or observed; (3) The initial and major cognitive impairment found in medical history inquiry and physical examination belongs to the following categories: amnestic manifestations; non-amnestic manifestations (language disorder, visual space disorder or executive dysfunction). 4. The subject should have a stable and reliable caregiver who can accompany the subject when necessary for examination or treatment.
Exclusion criteria
Exclusion criteria: 1. Have a history of seizures or convulsions; 2. Equipped with implantable devices (such as cardiac pacemakers, medical pumps or cochlear implants, etc.); any metal products (such as shrapnel, surgical clips or stents (except titanium), etc.) exist in the skull (not in the oral cavity); implanted Nerve stimulator (DBS or subcutaneous vagus nerve stimulator, etc.); 3. Cognitive decline caused by other reasons: cerebrovascular disease, central nervous system infection, Creutzfeldt-Jakob disease, Huntingtons disease and Parkinsons disease, Lewy body dementia, traumatic brain dementia, other physical and chemical factors (drugs, alcohol, CO, etc.) ), important physical diseases (hepatic encephalopathy, pulmonary encephalopathy, etc.), intracranial space-occupying disease (subdural hematoma, brain tumor), endocrine system disease (thyroid disease, parathyroid disease), vitamins or dementia caused by any other reasons; 4. Schizophrenia, bipolar disorder, major depression, delirium or other psychiatric disorders that meet the DSM-IV criteria; 5. Patients with uncorrectable visual and hearing impairments that cannot complete the scales and other related tests; 6. The researcher believes that the subject is unlikely to complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| scores of cognitive assessment battery; | — |
Countries
China
Contacts
Public ContactGang Wang
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed