Dermatomyositis
Conditions
Interventions
Group 1:Glucocorticoid + cyclophosphamide + cyclosporin
Group 2:Glucocorticoid + cyclophosphamide + Tofacitinib
Sponsors
Zhongshan Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. DM patients diagnosed according to Bohan/Peter's PM/DM classification criteria (Table 1); 2. Positive for MDA5 antibodies; 3. The study group identified at least one of the following skin manifestations: facial seborrheic dermatitis rash, microvascular morphological changes of fingernail wrinkles, Gottron syndrome/papules and reverse Gottron syndrome/papules, mechanic hands, skin ulcers and alopecia; 4. According to the medical history, physical examination, blood test, lung function, imaging and pathological examination, there is no confirmed ILD/RP-ILD; 5. Aged > 18 years; 6. The relevant medical data are complete.
Exclusion criteria
Exclusion criteria: 1. Patients with malignant tumors, lung diseases, other autoimmune diseases. 2. Patients who can not successfully complete the venous blood, chest HRCT and lung function. 3. Pregnancy. 4. Patients who give up active treatment during hospitalization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lung HRCT;pulmonary function;case fatality rate;incidence of respiratory failure; | — |
Countries
China
Contacts
Public ContactYang Ji
Zhongshan Hospital of Fudan University
Outcome results
None listed